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Cancer has been one of the top causes of death worldwide for decades despite the numerous types of therapy existing today. Improvement of early detection methods for preliminary stages of cancer, particularly stage I, would lead to sooner and thus more successful treatment; such a trend will exponentially increase cancer survival rates. Cancerous tumors are developed when the tumor suppressor protein p53 mutates and is no longer functional. Consequently, under p53’s absence of regulation, malignant cells are able to rapidly proliferate. As a result of the mutations, the protein survivin, an inhibitor of apoptosis, becomes highly expressed. Thus, the survivin promoter can be used as an indicator for cancerous tumors. We aim to create a diagnostic tool to detect early stages of cancer by placing a reporter gene, such as GFP, under the control of the survivin promoter. A positive diagnostic for a malignant tumor would hence activate the survivin promoter and turn on the indicator gene. We hope that our research will contribute to breakthroughs and real life applications in the field of cancer detection.

“Survivin” Cancer

School

Taipei American School
Taipei, Taiwan

BioBuilderClub Season

2021-2022 Season

Category

Resources

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