Tardigrades, also known as water bears, are micro-animals that can survive in extreme conditions. They contain a unique DNA-binding protein, damage suppressor protein (Dsup), which prevents and repairs DNA damage caused by UV radiation. We aim to develop a sunscreen using Dsup, which not only increases the resistance of UV damage, but also upregulates DNA damage repair genes when cells are exposed to UV radiation. We will express Dsup in Escherichia coli (E. coli), testing its effectiveness when bound to DNA in comparison to different types of traditional UV protection methods. These tests include comparing cell density over time when exposed to different levels of UV radiation. We will also purify Dsup and place it into different creams that will be tested for UV protection effectiveness. This tests whether Dsup is effective for UV protection as a layer on top of skin cells. We plan to express Dsup in Saccharomyces cerevisiae as well without affecting other cell functions to analyze its expression in eukaryotic cells. Ultimately, we aim to produce a product that can protect the skin from UV radiation more effectively than traditional sunscreen.