There are over 800 species of ticks worldwide, but only a few of those species are capable of transmitting disease to humans. One of those species is Ixodes scapularis, the black-legged tick. The species is responsible for the transmission of several severe illnesses, including Lyme disease. The Centers for Disease Control (CDC) estimates that over 400,000 people are diagnosed and treated for Lyme disease each year in the United States. Our goal for this project is to create a bio-friendly super-spray that utilizes enzymes from the fungus Beauveria bassiana. The fungal enzymes allow a breakdown of the I. scapularis cuticle that increase the tick’s mortality rate. People can then spray their clothes or other areas that are susceptible to ticks to control the I. scapularis population and reduce the spread of tick-borne diseases.