Shigella flexneri, a Gram-negative bacterial pathogen, is the causative agent of shigellosis, a highly contagious diarrheal disease that affects over 125 million people annually, with young children being particularly vulnerable. The infection spreads through contaminated food, water, or person-to-person contact in unsanitary conditions. The increasing prevalence of multidrug-resistant Shigella strains has rendered many antibiotics ineffective, posing a significant global health challenge. This research project focuses on genetically engineering a bacteria capable of detecting and neutralizing shigella’s quorum sensing system to prevent its pathogenic effects.