An extension of research, summarized in the article, introduces a bacteria-based fluorescence iodinated carbon monoxide (CO) biosensor, applicable to aerobic conditions. Upon finding that the bacteria Rhodospirillum rubrum is able to bind to CO and oxygen, and when bonded with oxygen is no longer able to bind with CO. R. rubrum can be used to induce expression of a red fluorescent protein (RFP) in an environment which is strictly CO composed. In order to make this concept applicable to a real world environment, where CO and oxygen compete to bind to the heme center of R. rubrum, an electrochemical flow reactor can be used. In order to reduce the oxygen bound to the R. rubrum heme complex which has a Fe3- center, to Fe2-, which is capable of binding with CO and expressing the RFP. This creates a carbon monoxide biosensor applicable to a real world environment.